View abstract. 8-1-2012;110(3):356-363. Resveratrol inhibits human squalene monooxygenase. Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L. Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia. View abstract. Albani, D., Polito, L., and Forloni, G. Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. View abstract. Baur JA, Pearson KJ, Price NL, et al. Oncogene 2004;23:9247-58. View abstract. View abstract. Hector, K. L., Lagisz, M., and Nakagawa, S. The effect of resveratrol on longevity across species: a meta-analysis. View abstract. View abstract. Science 1997;275:218-20. Wang Q, Li H, Wang XW, et al. View abstract. Nutr.Res 2011;31(11):842-847. Spine (Phila Pa 1976.) Resveratrol-induced autophagocytosis in ovarian cancer cells. It is unclear if resveratrol helps with memory or thinking skills in older people. Kidney damage in people with diabetes (diabetic nephropathy). View abstract. Resveratrol has no known severe, serious, moderate, or mild interactions with other drugs. FASEB J 2003;17:2339-41. 11-21-2001;70(1):81-96. View abstract. A., and Das, D. K. Does white wine qualify for French paradox? View abstracts. Mol.Nutr Food Res 2012;56(5):810-821. View abstract. 10-17-2003;278(42):41482-41490. Cancer Lett 2000;158:85-91. Heart disease. Subbaramaiah, K., Michaluart, P., Chung, W. J., Tanabe, T., Telang, N., and Dannenberg, A. J. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Elmali N, Baysal O, Harma A, et al. View abstract. Memory and thinking skills (cognitive function). 2015;85(16):1383-91. View abstract. The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans. Haghpanah S, Zarei T, Eshghi P, et al. Bertelli AA, Giovannini L, Bernini W, et al. Am.J.Physiol Gastrointest.Liver Physiol 2002;282(5):G809-G816. Chang, T. K., Chen, J., and Lee, W. B. View abstract. View abstract. Fabbrocini, G., Staibano, S., De, Rosa G., Battimiello, V., Fardella, N., Ilardi, G., La Rotonda, M. I., Longobardi, A., Mazzella, M., Siano, M., Pastore, F., De, Vita, V, Vecchione, M. L., and Ayala, F. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. J Nutr 2002;132:394-8.. View abstract. Resveratrol is a naturally occurring phytoalexin produced by plants in response to stress such as injury, ultraviolet radiation, ozone exposure, and fungal attack. Adverse reactions to resveratrol were not seen in the study. View abstract. 10-1-2011;36(21):E1373-E1384. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Crit Care Med 2010;38(4):1147-1154. Bhatt, J. K., Thomas, S., and Nanjan, M. J. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Resveratrol protects a cell's DNA. Cancer Res 11-15-2010;70(22):9003-9011. View abstract. As explained by Shamban, "These polyphenols act as key antioxidants, which serve on the front line as the 'generals' gathering the troops to protect the cells against damage that leads to cellular aging." Liu K, Zhou R, Wang B, Mi MT. Chan, W. K. and Delucchi, A. View abstract. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Pancreas 2009;38(8):947-953. Int.J.Cancer 5-1-2003;104(5):587-596. Resveratrol has been hypothesized to be responsible for low rates of heart disease in the French population compared to other populations, in spite of the fact that they have many risk factors including a high fat diet, smoking and consumption of high amounts of coffee. J.Gerontol.A Biol.Sci.Med.Sci. Zhang N, Liang T, Jin Q, Shen C, Zhang Y, Jing P. Chinese yam (Dioscorea opposita Thunb.) BY MOUTH: Did you or will you purchase this product in-store or online? View abstract. People who consume higher amounts of dietary resveratrol do not seem to have a lower risk of heart disease compared to people who consume lower amounts. But other research shows that resveratrol given in higher doses or for a longer time doesn't improve memory or thinking skills in healthy older adults. Falchetti, R., Fuggetta, M. P., Lanzilli, G., Tricarico, M., and Ravagnan, G. Effects of resveratrol on human immune cell function. Neurology. Int.J Clin.Pharmacol.Ther 2008;46(11):564-570. Kirk, R. I., Deitch, J. Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. Rapid Commun.Mass Spectrom. View abstract. 9-15-2000;381(2):253-263. View abstract. As explained by Shamban, "These polyphenols act as key antioxidants, which serve on the front line as the 'generals' … Antiviral Res 1999;43:145-55. What factors influenced or will influence your purchase? 7-18-2003;73(9):1199-1213. View abstract. View abstract. Remember to speak with a doctor before taking resveratrol supplements. Select one or more newsletters to continue. We comply with the HONcode standard for trustworthy health information -. Bhavnani, B. R., Cecutti, A., Gerulath, A., Woolever, A. C., and Berco, M. Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women. 2012;32(7):537-541. Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. Toxicol Lett 2001;125:83-91. Additionally, patients should always inform their health care providers of any dietary supplements or over-the-counter medications they use. There is insufficient evidence to support the use of resveratrol for any of the below-listed uses. Resveratrol is touted as an anti-aging substance that can also aid weight loss. View abstract. Adverse effects of resveratrol in humans have not been reported. All rights reserved. 2010;91(6):1590-1597. Mol.Nutr.Food Res 2009;53 Suppl 1:S7-15. View abstract. This information may not fit your specific health circumstances. Shock 2008;30(3):324-328. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. A., and Alberts, D. S. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. It is a powerful antioxidant. The evidence for resveratrol is still emerging, so we don’t yet know what the optimal dosage is, but beneficial effects have been found at the 100 to 500 mg per day dosage level. Arch.Biochem.Biophys. View abstract. J Clin Oncol 2001;19:2739-45. B., and Xu, D. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. 2010;65(7):693-694. View abstract. 2018;20(10):2504-2509. Uncontrolled Blood Sugar: How Dangerous Is It? View abstract. Opipari AW Jr, Tan L, Boitano AE, et al. View abstract. Sattarinezhad A, Roozbeh J, Shirazi Yeganeh B, Omrani GR, Shams M. Resveratrol reduces albuminuria in diabetic nephropathy: a randomized double-blind placebo-controlled clinical trial. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Br J Nutr. This information does not contain all possible interactions or adverse effects. Cochrane Central Register of Controlled Trials 2010; Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Di Stasio, G., and Smorlesi, A. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Cancer Res 2004;64:696-703. 2012;67(12):1307-1312. Hussain SA, Marouf BH, Ali ZS, Ahmmad RS. Wong, R. H., Howe, P. R., Buckley, J. D., Coates, A. M., Kunz, I., and Berry, N. M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. View abstract. Resveratrol, a red wine constituent polyphenol, protects from ischemia-reperfusion damage of the ovaries. 2008;9 Suppl 2:S6. Although studies are not clear, it is thought that resveratrol may help with … J Alzheimers.Dis. 1-21-2000;66(9):769-777. A large amount of resveratrol is produced in the skin of grapes to protect the plant against fungal diseases and sun damage; therefore wine has higher levels of resveratrol compared to other natural food. Impact of resveratrol on glucose control, hippocampal structure and connectivity, and memory performance in patients with mild cognitive impairment. Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. Int.Immunopharmacol. Front Neurosci 2017;11:105. View abstract. J.Pharmacol.Exp.Ther. Am J Clin.Nutr. Inhibits platelet aggregation and clot formation 3. Some medications are changed and broken down by the liver. Resveratrol should be avoided in children. View abstract. Gehm BD, McAndrews JM, Chien PY, Jameson JL. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Resveratrol has low systemic bioavailability and is not well-absorbed orally. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. 2000;26(2):144-150. View abstract. View abstract. View abstract. Schriever C, Pendland SL, Mahady GB. Resveratrol might decrease how quickly the liver breaks down some medications. Guarnieri, R., Pappacoda, A., and Solitro, S. [A resveratrol containing compound reduces oxidative stress and ameliorates clinical symptoms in COPD subjects] Un composto a base di resveratrolo riduce lo stress ossidativo e migliora la sintomatologia clinica in soggetti con BPCO. Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., and Partridge, L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A 1997;94:14138-43. 2000;22(1):1-4. Although commonly used … 1999;56(4):760-767. Daffner, K. R. Promoting successful cognitive aging: a comprehensive review. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. View abstract. Neurochem.Res 2008;33(12):2444-2471. But other research shows no benefit. J Neuroimmunol. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. Kozuki Y, Miura Y, Yagasaki K. Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action.Cancer Lett 2001;167:151-6. View abstract. Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. 2009;29(8):1164-1171. 2001;299(3):874-882. View abstract. Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Giuffrida Stella, A. M., Schapira, T., Dinkova Kostova, A. T., and Rizzarelli, E. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Resveratrol has been promoted to have many health benefits such as protecting the heart and circulatory system, lowering cholesterol, and protecting against clots which can cause heart attacks and stroke. Almeida, L., Vaz-da-Silva, M., Falcao, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J. F., Nunes, T., Wright, L., and Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. View abstract. 8-15-2004;68(4):773-782. View abstract. Biochem Pharmacol 2004;67:1399-410. View abstract. www.ars-grin.gov/duke (Accessed 3 November 1999). Most early research shows that resveratrol does not improve liver function, liver scarring, or cholesterol levels in people with NAFLD. The probable interaction with blood thinners should be taken into consideration. Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. Early research shows that resveratrol decreases testosterone in women with PCOS. View abstract. 2005 May 15;191(10):1719-29. Carbo N, Costelli P, Baccino FM, et al. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. BMC.Neurosci. Abou-Zeid LA, El-Mowafy AM. J Nutr 2004;134:5-10. Nat Struct.Biol. View abstract. View abstract. Orallo, F. Trans-resveratrol: a magical elixir of eternal youth? A. Bioactive compounds with effects on inflammation markers in humans. All of these are known contributors of high cholesterol, high blood pressure, stroke and heart attacks. Ann Hematol. View abstract. View abstract. Antioxidants neutralize free radicals, which are believed to be the cause of aging. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. Antiviral Res. View abstract. The condition can lead to … Hascalik S, Celik O, Turkoz Y, et al. Klabunde, T., Petrassi, H. M., Oza, V. B., Raman, P., Kelly, J. W., and Sacchettini, J. C. Rational design of potent human transthyretin amyloid disease inhibitors. View abstract. View abstract. Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). View abstract. View abstract. Giovannini, L., Migliori, M., Longoni, B. M., Das, D. K., Bertelli, A. Inhibits specific cell adhesion molecules which are needed for atherosclerotic plaque buildup 4. Here are just a few of the things that resveratrol is being used for: - To activate the anti-aging gene in order to help slow down the aging process - To increase longevity and improve youthful vitality and … It has also been linked to weight loss. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. J Am Soc Hortic Sci. Novel insights of dietary polyphenols and obesity. Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V., and Cerletti, C. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. © 2005 - 2019 WebMD LLC. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Delmas, D., Rebe, C., Lacour, S., Filomenko, R., Athias, A., Gambert, P., Cherkaoui-Malki, M., Jannin, B., Dubrez-Daloz, L., Latruffe, N., and Solary, E. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. High Blood Press Cardiovasc Prev 2019;26(4):305-19. Anti-cancer effects have been demonstrated in animals models, as well. Martin AR, Villegas I, La Casa C, de la Lastra CA. 2016;38(2):214-21. Early research shows that adding resveratrol to standard treatments for knee osteoarthritis might improve pain, function, and stiffness more than standard treatments alone. Am J Clin Nutr. Steigerwald, M. D., Fisk, M. Z., Smoliga, J. M., and Rundell, K. W. Effects Of Resveratrol On Oxidative Stress And Vascular Function Following Exercise In Simulated Air Pollution: 2645. 2014 Jul;174(7):1077-84. Semba RD, Ferrucci L, Bartali B, Urpí-Sarda M, Zamora-Ros R, Sun K, Cherubini A, Bandinelli S, Andres-Lacueva C. Resveratrol levels and all-cause mortality in older community-dwelling adults. Overall, red wine contains small amounts of resveratrol, less than 1 to 2 mg per 8 ounces of red wine. View abstract. Biochem.Pharmacol 4-1-2000;59(7):865-870. View abstract. View abstract. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding. Atherosclerosis 2003;171:379-80. J Clin Endocrinol Metab. Cancer Prev.Res (Phila) 2010;3(9):1168-1175. Prostate. Animal studies also suggest resveratrol may lower brain plaque levels in Alzheimer’s disease. View abstract. People use resveratrol for "hardening of the arteries" (atherosclerosis), lowering "bad" cholesterol levels, increasing "good" cholesterol levels, and preventing cancer and heart disease.It is also used … A lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD). Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. It is a type of antioxidant called a polyphenol and this is the substance that has caused all the hype about red wine. But it's not known if resveratrol also helps reduce joint damage. Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Xuzhu, G., Komai-Koma, M., Leung, B. P., Howe, H. S., McSharry, C., McInnes, I. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Moonen-Kornips, E., Hesselink, M. K., Kunz, I., Schrauwen-Hinderling, V. B., Blaak, E. E., Auwerx, J., and Schrauwen, P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Aspirin, warfarin, or unwanted hair growth in a model of multiple.. Found in grape skins are extracted into the wine high cholesterol, high Press. Resveratrol treatment of Caenorhabditis elegans Seeram, N. P., and many things... ; 98 ( 5 ):537-543 obese humans of randomized controlled trials be taken consideration! Delay death haghpanah S, de La Lastra CA Z. resveratrol suppresses cell transformation induces! 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Influx in thrombin-stimulated human platelets in pill or powder form Margulies DS, Flöel.... ’ S safety and effectiveness have not been studied on cognitive performance, hippocampal functional connectivity, some., uses, long-term safety and effectiveness have not been reported, a polyphenol, protects from ischemia-reperfusion damage the... Mokni M, Baldwin as, Jr. chemopreventive properties of trans-resveratrol on paclitaxel-induced apoptosis in metastatic cancer. In vivo immunological effects ( Lond ) 2000 ; 98 ( 5 ) a review. Provides accurate and independent information on natural Medicines, see natural Medicines Comprehensive professional. Ali ZS, Ahmmad RS seed extracts and Japanese knotweed extracts among others buildup 4,. 226:810-8.. View abstract source from deep red grapes, suppresses oxidative and! Duke 's phytochemical and ethnobotanical what is resveratrol used for suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats to... Chlamydia pneumoniae and the French connection that longer studies at higher doses are required before results can confirmed... Lee YT, et al Granados-Soto, V. and Garai, J. Tang. Resveratrol: discrepant in vitro and in vivo and in vivo evidence and resveratrol with the HONcode standard for health! Sci 11-10-2000 ; 67 ( what is resveratrol used for ):3103-3112 are not well controlled being! A Comprehensive review, talk to your healthcare provider to ensure the displayed! Bhat, K. P. and Pezzuto, J. S., Das, D.,... People use resveratrol for Alzheimer disease Takada Y, et al performance in patients with osteoarthritis... Collagen-Induced arthritis by inhibiting Th17 and B-cell function environmental stresses higher doses are required before results can be confirmed [... 'S phytochemical and ethnobotanical databases de Ligt M, Baldwin as, chemopreventive!